“The main pathological effect of ingestion of massive doses of vitamin D is widespread calcification of soft tissues. Pathological changes in these tissues are observed to be inflammation, cellular degeneration, and calcification. Diffuse calcification affects joints, synovial membranes, kidneys, myocardium, pulmonary alveoli, parathyroids, pancreas, lymph glands, arteries, conjunctivae, and cornea. More advanced cases interfere with cartilage growth. The abnormal calcification is grossly observed as a whitish chalky material, and kidney insufficiency is the most critical development of these processes. Initial kidney damage is due to calcium deposition in distal tubules, causing inflammation and later obstruction, which in turn causes hypertension and pathology related to it. As would be expected, the skeletal system undergoes a simultaneous demineralization that results in the thinning of bones.”