“Just like estrogen, NO has physiological role but it is limited and reserved for times of stress. With the exception of Viagra pretty much all other drugs on the market that deal with NO actually try to lower it, not raise it. And in the case of Viagra, look at its side effects and the studies on PubMed for its long term use — short term it can cause heart attacks and/or strokes, while chronically elevated NO causes CVD, MS, AD, PD, and other degenerative conditions.”

“Our hypothesis is that recurrent infections over the life span play a significant role in producing aging changes in all systems outside the blood-brain barrier via release of toxic quantities of NO. NO may be a major factor in the development of coronary heart disease (CHD). Considerable evidence has accrued indicating a role for infections in the induction of CHD and, indeed, patients treated with a tetracycline derivative had 10 times less complications of CHD than their controls. Stress, inflammation, and infection have all been shown to cause induction of iNOS in rats, and it is likely that this triad of events is very important in progression of coronary arteriosclerosis leading to coronary occlusion. Aging of the anterior pituitary and pineal with resultant decreased secretion of pituitary hormones and the pineal hormone, melatonin, respectively, may be caused by NO.”

https://www.ncbi.nlm.nih.gov/pubmed/9951625