Lipofuscin + Transition Metals = Double Trouble. Excess omega 3 fatty acids (DHA, EPA, ALA, etc.) + transition metals (iron, copper, zinc, etc.) = accelerated aging. Annika Höhn, Tobias Jung, Stefanie Grimm, & Tilman Grune (“Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells,” Free Radical Biology and Medicine, Apr. 2010)…

Did you know I’m the Sunnier Semmelweis of Holistic Health? Ignaz Semmelweis (1818-1865) was considered insane for promoting antiseptic procedures. He denounced doctors who didn’t wash their hands as “irresponsible murderers.” He was rewarded for his efforts by being beaten to death by guards in an asylum. He was vindicated years after his death, and…

Acute Yellow Fat Disease is rarer in dogs than chronic Yellow Fat Disease. Chronic Yellow Fat Disease is subclinical — without severe or readily observable symptoms. Biological aging is closely associated — almost-but-not-quite synonymous — with Broad-Spectrum Yellow Fat Disease. Chronological aging is very different from biological aging — although the beaker boys will undoubtedly…

Lipofuscin accumulates in the ears as well as many other parts of the body. It’s the cause of Broad-Spectrum Yellow Fat Disease (cumulative lipofuscinosis). Lipofuscin is often associated with “aging,” but I beg to differ. It’s not the length of the journey that breaks us down — it’s the condition of the roadway. Are we…

Why did biological gerontologists (the eggheads who study why people age) think lipofuscin was irrelevant to aging? Because there was so much of it — as much as 20% of cellular mass. Isn’t that a lot like thinking cars are irrelevant to traffic because there are too many of them? Or like thinking pigeons are…