The Limbo-Stick Game

Losing floods the brain with neurotoxic endorphins and enkephalins. Endorphins, enkephalins, and other opioid agonists cause brain damage and rigidity of the neck and back muscles. Because humans lose from time to time, opioid agonists are a secondary reward (along with serotonin). Dopam... Read More

Rube Goldberg Histotripsy

News: "Histotripsy Destroys Liver Tumors with Sound Waves." KILLING a cancer cell is like killing a bee in a bee swarm. Ray Peat knew cancer is a "systemic metabolic disorder rooted in cellular respiration defects." KILLING an incipient organ means big bucks for Wall Street. <> AI Overvi... Read More

Metformin?

AI Overview: "Ray Peat, the late biologist and nutritionist, viewed metformin as counterproductive to optimal cellular energy. His 'pro-metabolic' philosophy focuses on maximizing mitochondrial respiration and carbon dioxide production, which he believed metformin inhibits. "Specifically, Peat ar... Read More

Serotonin (Kruse & Peat)

Ray Peat's advice saved my life in 2015. If I'd followed Jack Kruse's advice, I'd be dead and cremated. <> AI Overview: "Jack Kruse, MD, and Ray Peat, PhD, largely disagree on the fundamental nature of serotonin. Kruse views serotonin as a beneficial, solar-driven mediator of circadian biology... Read More